TTN Lower limbs

Lower-limb muscle MR images were reviewed and, if available, 30 muscles were systematically scored with a modified Mercuri score system. Extensor digitorum longus and extensor hallucis longus were evaluated together. A normal muscle was scored by 0. A score of 1 for scattered small areas of increase density. If muscle was replaced in a 30-60%, we scored 2 and if the replacement implies 60-90%, 3. A score of 4 was used for muscles with complete or nearly complete fat replacement. Each patient was evaluated by two independent reviewers (DGA and LCC). Discrepancies were discussed, and a final score was decided by consensus. Significant asymmetric involvement between right and left limb was also evaluated in each muscle.<br>

对下肢肌肉磁共振（MR）图像进行审阅，若图像可用，则采用改良Mercuri评分系统对30块肌肉开展系统化评分。其中，趾长伸肌与拇长伸肌合并评估。正常肌肉评分为0分；出现散在小片密度增高区域时评1分；若肌肉被替代的比例为30%~60%，则评2分；替代比例达60%~90%时，评3分。肌肉完全或近乎完全被脂肪替代时，评4分。每位患者由两名独立审阅者（DGA、LCC）分别评估，若出现评分分歧，则通过讨论达成共识以确定最终评分。此外，还针对每块肌肉评估了左右下肢间是否存在显著不对称的受累情况。