Transcriptional profiling of natural and synthetic chromosomal inversions

Here, we characterize differential expression patterns associated with two chromosomal inversions found in natural Drosophila melanogaster populations. To isolate the impacts of genome structure, we engineered synthetic chromosomal inversions on controlled genetic backgrounds with breakpoints that closely match each natural inversion.本研究旨在表征黑腹果蝇（Drosophila melanogaster）自然种群中发现的两种染色体倒位相关的差异表达模式。为了单独分离基因组结构的影响，我们在遗传背景可控的实验体系中，构建了断裂点与每种自然倒位高度匹配的人工合成染色体倒位。