IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

本提案中的IBS BAG包含IBS团队以及来自iRTSV/CEA（格勒诺布尔）、CEA-卡达拉什（圣保罗莱兹迪朗斯）和IRBA（布雷蒂尼叙尔奥尔日）的外部合作组。我们聚焦人类健康、生物技术及方法学领域，研究蛋白质的结构-功能关系。多数项目是MX-2329提案的延续，可归为以下不同主题：宿主-病原体相互作用、新型药物靶点、基础细胞机制、膜蛋白、内在无序蛋白、生物技术应用及方法学。部分项目采用整合方法（X射线晶体学、小角X射线散射（SAXS）、核磁共振（NMR）及冷冻电镜（cryo-EM）），结合其他生物物理研究，旨在全面解析所研究生物大分子系统的复杂性。部分团队致力于串行晶体学及其发展，而ESRF-EBS已成为该领域的理想工具。