Placental and Maternal Microbiome Adaptations in a Preeclampsia-Like Mouse Model with Obesity

This study examined the maternal microbiome across multiple body sites in BPH/5 mice, a model of preeclampsia and obesity, and C57 controls, using 16S rRNA sequencing. Results revealed strain- and site-specific microbial differences, including distinct placental microbiomes and potential vertical microbial transmission influenced by maternal metabolic state.

本研究采用16S rRNA测序技术，针对作为子痫前期与肥胖模型的BPH/5小鼠及C57对照组小鼠的多部位母体微生物组展开分析。结果显示，不同小鼠品系与采样部位的微生物组存在特异性差异，包括特征鲜明的胎盘微生物组，以及受母体代谢状态影响的潜在垂直微生物传播现象。