Methylation analysis for plasma DNA of patients with organ transplantation
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https://www.omicsdi.org/dataset/ega/EGAS00001004788
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We developed Genetic-Epigenetic Tissue Mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived.EGA study EGAS00001004788
本研究开发了遗传-表观遗传组织图谱（Genetic-Epigenetic Tissue Mapping，GETMap），通过将携带非生殖系基因组遗传变异的血浆DNA的甲基化谱与相关组织进行比对，以确定其组织组成。本研究通过验证该方法证实：在孕妇体内，携带胎儿特异性等位基因的循环DNA完全源自胎盘组织。EGA研究 EGAS00001004788
创建时间：
2021-04-15
