Mus musculus Genome sequencing and assembly. Mus musculus

The study goals focus on investigating the therapeutic effects of probiotic interventions on rheumatoid arthritis (RA) in a mouse model, while concurrently examining the differences in gut microbiota composition among treatment groups. The relevance of this research lies in the potential for probiotics to modulate gut microbiota, which have been implicated in the pathogenesis of RA. By comparing the gut microbial profiles of mice treated with probiotics versus controls, the study aims to identify specific microbial changes that correlate with disease improvement. This understanding may reveal novel mechanisms underlying the immunomodulatory effects of probiotics in RA and facilitate the development of targeted microbial-based therapies. Additionally, the study contributes to the growing body of evidence on the gut-joint axis, emphasizing the interconnectedness of gut health and inflammatory diseases beyond the gastrointestinal tract. Ultimately, the findings of this research could lead to improved treatment strategies for RA patients, leveraging the power of the gut microbiome to promote disease remission and overall health.

本研究旨在探究益生菌干预对小鼠类风湿关节炎（rheumatoid arthritis, RA）模型的治疗效果，同时分析各干预组间肠道菌群（gut microbiota）组成的差异。本研究的价值在于，益生菌具备调节肠道菌群的潜力，而肠道菌群已被证实与类风湿关节炎的发病机制密切相关。本研究通过对比益生菌干预组与对照组小鼠的肠道微生物谱，旨在筛选出与疾病改善相关的特异性微生物变化。该研究成果或可揭示益生菌在类风湿关节炎治疗中发挥免疫调节作用的全新机制，并助力靶向微生物疗法的开发。此外，本研究可为肠-关节轴相关研究积累更多实证依据，强调肠道健康与胃肠道外炎症性疾病之间的内在关联。最终，本研究结果或可优化类风湿关节炎患者的治疗方案，通过利用肠道微生物组（gut microbiome）的作用助力疾病缓解与整体健康水平提升。