Proteus mirabilis bloodstream infection in Internal Medicine

A retrospective study on Proteus mirabilis bloodstream infections in SESARAM EPERAM Internal Medicine Department from between January 1st 2014 and December 31nd 2019 focusing in the composite endpoint of occurrence of in-hospital death or intensive care unit admission. The sample was composed of 38 cases. Twenty-four were male (63.3%). The mean age was 77.0 years (standard deviation 13.3). Three patients (7.9%) required ICU care. Nine patients died in the hospital (23.7%). Among these, we found a higher proportion of: nursing home residents (66.5% versus 24.1% p = 0.019), alcoholism (44.4% versus 13.8% p = 0.049) and isolation of second bacteria in peripheral blood (44.4% versus 13.8% p = 0.049). As independent predictors of the outcome under study we found alcoholism (odds ratio [OR] 11.8 p = 0.031) and multimicrobial isolation (OR 16.2. P = 0.032).

本研究为一项回顾性研究，针对2014年1月1日至2019年12月31日期间于SESARAM EPERAM内科病房收治的奇异变形杆菌（Proteus mirabilis）血流感染患者展开，研究以院内死亡或入住重症监护病房（Intensive Care Unit, ICU）作为复合终点。本研究共纳入38例患者，其中男性24例（占比63.3%），平均年龄为77.0岁（标准差13.3）。3例患者（7.9%）需接受重症监护病房救治，9例患者于院内死亡（占比23.7%）。在发生上述复合终点的患者中，以下指标的占比显著更高：养老院入住者（66.5% vs 24.1%，p=0.019）、酒精成瘾者（44.4% vs 13.8%，p=0.049）以及外周血分离到第二种病原菌者（44.4% vs 13.8%，p=0.049）。本研究发现，酒精成瘾（优势比[odds ratio, OR]=11.8，p=0.031）与多重微生物分离（优势比[odds ratio, OR]=16.2，p=0.032）是本次研究结局的独立预测因素。