Extended Data Fig. 5

C1R cells expressing different alleles of MICA were incubated with PBMCs from healthy donors and 10 µg/ml of MICAB1-Fc-engineered, MICAB1-Fc silent or isotype control Fc-engineered mAb for 24 hours. The data shown are the frequencies of NK cells expressing CD137 among total NK cells, and are representative of three independent experiments

将表达不同MHC I类链相关蛋白A（MICA）等位基因的C1R细胞，与健康供者的外周血单个核细胞（PBMC）以及10 μg/mL的MICAB1-Fc工程化、MICAB1-Fc沉默型或同型对照Fc工程化单克隆抗体（monoclonal antibody，mAb）共同孵育24小时。本次展示的数据为总自然杀伤细胞（NK细胞）中表达CD137的NK细胞占比，该结果为三次独立实验的代表性数据。