Additional file 1 of Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis

Supplementary Material 1: Supplementary data 1. Leave-one-out analysis between cathepsins and different diabetic chronic complications. Supplementary Table 1. Characteristics of SNPs serving as instrumental variables. Supplementary Table 2. The results of bidirectional MR analysis between six cathepsins and the risk of nine diabetic chronic complications. Supplementary Table 3. Multivariable MR analysis of cathepsins and different diabetic chronic complications. Supplementary Table 4. The results of cis-eQTL MR and SMR analysis. Supplementary Table 5. 577 differentially expressed genes identified from GSE94019 based on the median expression expression of Cathepsin H. Supplementary Table 6. The causal effects of immunophenotypes on DR, PDR, and diabetic maculopathy, and the causal effects of Cathepsin H on immunophenotypes associated with DR, PDR, or diabetic maculopathy.

补充材料1：补充数据集1。组织蛋白酶与各类糖尿病慢性并发症之间的留一法分析。
补充表1：作为工具变量（Instrumental Variables）的单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）特征信息。
补充表2：6种组织蛋白酶与9种糖尿病慢性并发症患病风险之间的双向孟德尔随机化（Mendelian Randomization, MR）分析结果。
补充表3：组织蛋白酶与各类糖尿病慢性并发症的多变量孟德尔随机化分析结果。
补充表4：顺式表达数量性状位点孟德尔随机化（cis-eQTL MR）及SMR分析结果。
补充表5：基于组织蛋白酶H（Cathepsin H）中位表达水平，从GSE94019数据集筛选得到的577个差异表达基因。
补充表6：免疫表型对糖尿病视网膜病变（Diabetic Retinopathy, DR）、增殖性糖尿病视网膜病变（Proliferative Diabetic Retinopathy, PDR）及糖尿病黄斑病变的因果效应，以及组织蛋白酶H对与DR、PDR或糖尿病黄斑病变相关的免疫表型的因果效应。