Nr4a transcription factors limit CAR-T cell function in solid tumors [RNA-Seq]

Chromatin accessibility with ATAC-seq and gene expression with RNA-seq for CD8 T cells expressing chimeric antigen receptors in solid tumors or after in vitro culture. Overall design: RNA-Seq: 47 samples针对实体瘤中或经体外培养的表达嵌合抗原受体（chimeric antigen receptors）的CD8阳性T细胞，采用转座酶可及性测序（ATAC-seq）检测其染色质开放性，同时利用RNA测序（RNA-seq）分析其基因表达情况。实验设计概况：RNA测序样本共计47份。