Pancreatic Ductal Adenocarcinoma (PDAC) Clinical Trials Dataset: Cross-Registry US and EU Data

PDAC Trial Atlas dataset (v1.3) PDAC Trial Atlas is a curated, pancreas ductal adenocarcinoma (PDAC)–focused dataset of clinical trials, enriched with normalization, tagging, and cross-registry correlation to support exploration and lightweight analysis. The dataset provides a unified, local-friendly table of PDAC-relevant clinical trials sourced from major international registries, with harmonized fields designed to accelerate filtering, comparison, and downstream analysis. Purpose Provide a single, analysis-ready table of PDAC-relevant clinical trials. Normalize key trial attributes (therapeutic class, focus tags, intervention types, design). Correlate and merge records appearing across multiple registries when explicit links exist. Data sources ClinicalTrials.gov — U.S./international clinical trial registry accessed via public API. CTIS (EU Clinical Trials Information System) — accessed via programmatic retrieval from the public CTIS portal. Notes CTIS public coverage applies primarily to EU/EEA trials submitted under the EU Clinical Trials Regulation (CTR), with public availability from 31 January 2022 onward. Legacy EU trials registered exclusively in EudraCT are not included in this v1.3 release. Dataset size Total trials: 2,476 By source: ClinicalTrials.gov: 2,324 CTIS: 117 ClinicalTrials.gov + CTIS (merged records): 35 Each row represents a unique PDAC-relevant trial after de-duplication and correlation. Files included pdac-trials.csv — UTF-8 CSV with a stable, documented header. pdac-trials.parquet — Parquet version of the same table (optimized for analytics). schema.json — Machine-readable schema describing all fields. Field overview Key fields include: Trial identifiers (nct_id, secondary_id) Registry source and links (source, trial_link) Trial metadata (title, phase, status, sponsor, dates) Conditions and interventions Outcomes and eligibility criteria Locations and summaries Normalized analytic fields: therapeutic_class focus_tags intervention_types study_design PDAC inclusion rationale (pdac_match_reason) Missing values are represented as NA. Methodology Ingestion of PDAC-focused trial records into a local SQLite database (pdac_trials.db): ClinicalTrials.gov retrieval CTIS retrieval De-duplication and correlation of CTIS trials referencing an NCT identifier. Normalization, tagging, and heuristic classification. Export to CSV and Parquet formats. Generation timestamp (UTC): 2026-02-05 20:24:09Z Limitations This dataset is not a complete or authoritative mirror of any registry. PDAC relevance is determined via heuristic string matching and normalization rules; false positives and negatives may occur. Registry data availability varies; some fields may be incomplete or simplified. Detection of publications and results is best-effort and may lag behind registry updates. CTIS records are only merged with ClinicalTrials.gov when an explicit identifier link is present. License This dataset is released under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.See LICENSE-CC-BY-4.0.txt for details.胰腺导管腺癌（PDAC，pancreas ductal adenocarcinoma）试验图谱数据集（v1.3版） 胰腺导管腺癌试验图谱是一款聚焦胰腺导管腺癌的经甄选整理的临床试验数据集，通过标准化处理、标签标注与跨注册库关联分析进行增强，旨在支持探索性研究与轻量化分析工作。 该数据集整合了来自全球主要国际临床试验注册库的PDAC相关临床试验，构建了本地化友好的统一表格，其统一规范的字段可有效加速筛选、对比与下游分析流程。 ## 研究目标 1. 提供一份可直接用于分析的PDAC相关临床试验统一表格 2. 对临床试验的关键属性（治疗类别、聚焦标签、干预类型、试验设计）进行标准化处理 3. 当存在明确关联关系时，对跨多个注册库的重复记录进行关联与合并 ## 数据来源 1. ClinicalTrials.gov：美国及国际临床试验注册库，通过公开API获取数据 2. CTIS（欧盟临床试验信息系统，EU Clinical Trials Information System）：通过公开CTIS门户以编程方式获取数据 ## 备注说明 1. CTIS的公开覆盖范围主要针对依据《欧盟临床试验法规（CTR，EU Clinical Trials Regulation）》提交的欧盟/欧洲经济区（EU/EEA）临床试验，且数据公开起始时间为2022年1月31日 2. 本次v1.3版未纳入仅在EudraCT注册的欧盟旧版临床试验 ## 数据集规模 总试验数量：2476项 按来源划分： - ClinicalTrials.gov：2324项 - CTIS：117项 - ClinicalTrials.gov与CTIS合并记录：35项 表格中每一行均代表经过去重与关联处理后的唯一PDAC相关临床试验。 ## 包含文件 1. pdac-trials.csv：采用UTF-8编码的CSV文件，包含稳定且文档化的表头 2. pdac-trials.parquet：同表格的Parquet格式版本，针对分析场景进行了优化 3. schema.json：描述所有字段的机器可读格式架构文件 ## 字段概览 核心字段包括： - 试验标识符（nct_id、secondary_id） - 注册库来源与链接（source、trial_link） - 试验元数据（标题、试验阶段、状态、申办方、日期） - 适应症与干预措施 - 试验结局与入排标准 - 试验地点与概述 标准化分析字段： therapeutic_class、focus_tags、intervention_types、study_design，以及PDAC匹配依据（pdac_match_reason） 缺失值以NA表示。 ## 构建方法 将PDAC聚焦的临床试验记录导入本地SQLite数据库（pdac_trials.db）： 1. ClinicalTrials.gov数据获取 2. CTIS数据获取 3. 对引用NCT标识符的CTIS试验进行去重与关联处理 4. 标准化处理、标签标注与启发式分类 5. 导出为CSV与Parquet格式 生成时间戳（UTC）：2026-02-05 20:24:09Z ## 局限性说明 1. 本数据集并非任何注册库的完整或权威镜像 2. PDAC相关性通过启发式字符串匹配与标准化规则判定，可能存在假阳性与假阴性结果 3. 各注册库的数据可用性存在差异，部分字段可能不完整或经过简化处理 4. 对已发表研究与试验结果的识别为尽力而为模式，可能滞后于注册库的更新 5. 仅当存在明确的标识符关联关系时，才会将CTIS记录与ClinicalTrials.gov记录进行合并 ## 授权许可 本数据集采用知识共享署名4.0国际通用（CC BY 4.0，Creative Commons Attribution 4.0 International）许可协议发布，详细信息请参见LICENSE-CC-BY-4.0.txt文件。