Cellular pathways regulated by GH in hypothyroid-orchidectomized rat liver.

The genes differentially-expressed in the livers were identified by DNA microarrays as described under Material and Methods. DAVID was used to identify the hepatic KEEG pathways that were affected by GH. The table shows pathway name, up- and down-regulated genes, P value, and corrected P value (Benjamini). Abbreviations: carbamoyl-phosphate synthetase-1 (CPS1); ornithine carbamoyltransferase (OTC); argininosuccinate synthase (ASS1); acyl-CoA oxidase 1, palmitoyl (ACOX-1); angiopoietin-like 4 (ANGPTL4); diacylglycerol O-acyltransferase 2 (Dgat2); glutamate dehydrogenase 1 (GLUD-1); Lactate dehydrogenase A (LDH-A); stearoyl-CoA desaturase (Scd); estrogen sulfotransferase (SULT).

按照材料与方法部分所述的实验方案，通过DNA微阵列（DNA microarray）鉴定了肝脏组织中的差异表达基因。使用DAVID工具，鉴定了受生长激素（GH）调控的肝脏KEGG通路。本表格展示了通路名称、上调与下调基因、P值以及经Benjamini方法校正后的P值。缩写说明：氨基甲酰磷酸合成酶1（carbamoyl-phosphate synthetase-1, CPS1）；鸟氨酸氨甲酰转移酶（ornithine carbamoyltransferase, OTC）；精氨酸琥珀酸合成酶1（argininosuccinate synthase, ASS1）；脂酰辅酶A氧化酶1（棕榈酰型，acyl-CoA oxidase 1, palmitoyl, ACOX-1）；血管生成素样蛋白4（angiopoietin-like 4, ANGPTL4）；二酰甘油O-酰基转移酶2（diacylglycerol O-acyltransferase 2, Dgat2）；谷氨酸脱氢酶1（glutamate dehydrogenase 1, GLUD-1）；乳酸脱氢酶A（Lactate dehydrogenase A, LDH-A）；硬脂酰辅酶A去饱和酶（stearoyl-CoA desaturase, Scd）；雌激素磺基转移酶（estrogen sulfotransferase, SULT）。