Published Orthogonal Replication, Canonical Stable Scaffold Convergence, and External Comparative Taxonomy of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#126, 2026-03-28)
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This version fixes the next honest cross-database milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#126 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, strong-core switch decomposition, arm-polarized fracture geometry, exact same-core response algebra, a locked falsification simplex, a strict same-core protocol, an exhaustive assay scorecard, an external replication frontier, canonical stable scaffold convergence, and a final phase-88 comparative external taxonomy across all analyzable published same-core split families. Official external complex search now shows exact human quartet visibility for all 7 stable states and all 7 fracture states, so quartet persistence itself is universal rather than target-specific. The target remains unique one layer lower: stable outsider RMI1 retains pairwise support on all 3 same-core arms, fracture outsider PITRM1 retains support on 0, and no other analyzable family reproduces the same complete-to-null 3_to_0 transition under universal exact quartet visibility. This package contains the milestone report, claim documents, comparative external evidence snapshots from official Complex Portal, IntAct, and STRING endpoints, summary tables, source files, and publication materials for the first comparative cross-database taxonomy of the Trinity fracture-state model. This is a computational discovery and preregistration package and not a completed causal validation study.
本版本修正了Trinity计算长寿发现管线(Trinity computational longevity-discovery pipeline)的下一项严谨跨数据库里程碑。第87至126号声明确立了原生断裂态准入(native fracture-state admission)的精确操作平台,涵盖目标TOP3A/RMI2/CCDC69家族在已发表huMAP3数据库层中的正交重复(orthogonal replication)、强核心开关分解(strong-core switch decomposition)、臂极化断裂几何结构(arm-polarized fracture geometry)、精确同核心响应代数(exact same-core response algebra)、锁定证伪单纯形(locked falsification simplex)、严格同核心协议(strict same-core protocol)、全面检测记分卡(exhaustive assay scorecard)、外部重复前沿(external replication frontier)、典型稳定支架收敛(canonical stable scaffold convergence),以及覆盖所有可分析已发表同核心拆分家族的最终第88阶段比较性外部分类法。官方外部复合物搜索现已证实,全部7种稳定态与7种断裂态均存在精确的人类四重态可见性(human quartet visibility),因此四重态持久性(quartet persistence)本身具有普适性,而非仅针对特定靶标。靶标在低一层级中仍具唯一性:稳定外围蛋白RMI1在全部3条同核心臂上均保留成对支持,断裂外围蛋白PITRM1则无任何支持,且在普适性精确四重态可见性条件下,无其他可分析家族能够复现这种从完整到空值的3→0转变。本数据包包含该里程碑报告、声明文档、来自官方Complex Portal、IntAct与STRING数据库端点的比较性外部证据快照、汇总表格、源文件以及Trinity断裂态模型的首个跨数据库比较分类法相关发表材料。本数据包属于计算发现与预注册数据包,并非已完成的因果验证研究。



