Effect of 20-Hete and dietary restriction on murine kidneys

Transcriptomic dataset of 15 murine kidneys of 14-week-old male C57Bl6 mice. Mice were divided into 3 treatment groups four weeks prior to nephrectomy and 5 mice had ad libitum (AL) access to food and water, while another 10 mice received 30% food restriction (CR). Calorically restricted mice either received intraperitoneal supplementation of 20-HETE (HETE) or vehicle (Veh, EtOH in sodiumchloride 0.9%) for 8 days on a daily basis prior to nephrectomy. Ad libitum fed mice received vehicle injections for 8 days on a daily basis prior to nephrectomy.

本数据集涵盖14周龄雄性C57Bl6小鼠的15个肾脏转录组样本。小鼠于肾切除术前4周被划分为3个处理组：其中5只小鼠可自由采食饮水（ad libitum, AL）；剩余10只小鼠接受30%食物限制（CR）。接受食物限制的小鼠在肾切除术前每日接受腹腔注射，分别补充20-HETE（HETE）或溶剂对照（Veh，即溶于0.9%氯化钠溶液的乙醇），持续8天；自由采食组小鼠则在肾切除术前每日接受溶剂对照注射，持续8天。