The effects of propofol and midazolam on rat spermatogenic parameters

ABSTRACT There is a need for various anesthetic agents to obtain sperm in the field of human and veterinary medicine. Propofol and midazolam are among the most preferred among these agents. The aim of this study was to determine how sperm paramaters are affected according to the anesthetic agent used. Propofol (2mg/kg) and midazolam (3,5-7,5mg/kg) were administered twice a day (morning-evening) for one week. As a result of this study, there was no statistical difference in sperm density and abnormal sperm rates (respectively P=0,673, P=0,479). Sperm motility rates are similar in the control and propofol groups, while the motility rate in the midazolam group is statistically lower. (Control group � - Midazolam group h.75 - Propofol group �.75), (P

摘要：在人类医学与兽医学领域，获取精子样本需使用多种麻醉剂。异丙酚（Propofol）与咪达唑仑（Midazolam）是此类药物中最受青睐的两类。本研究旨在明确不同麻醉剂对精子参数的影响。研究中每日早晚各给药一次，连续给药一周，其中异丙酚给药剂量为2mg/kg，咪达唑仑给药剂量为3.5~7.5mg/kg。本研究结果显示，精子密度与精子畸形率均无统计学差异（对应P值分别为0.673、0.479）。对照组与异丙酚组的精子活动率相近，而咪达唑仑组的精子活动率则存在统计学意义上的降低。（对照组 � - 咪达唑仑组 h.75 - 异丙酚组 �.75），(P