A scoping review of graphene-based biomaterials for in vivo bone tissue engineering. Library and Dataset.

<b>Files contains manuscripts/abstracts to be uploaded to Rayyan without duplicates and EndNote Library.</b><br><b>Abstract: </b>The growing demand for more efficient materials for medical applications brought together two previously distinct fields: medicine and engineering. Regenerative medicine has evolved with the engineering contributions to improve materials and devices for medical use. In this regard, graphene is one of the most promising materials for bone tissue engineering and its potential for bone repair has been studied by several research groups. The aim of this study is to conduct a scoping review including articles published in the last 12 years (from 2010 to 2022) that have used graphene and its derivatives (graphene oxide and reduced graphene) in preclinical studies for bone tissue regeneration, searching in PubMed/MEDLINE, Embase, Web of Science, Cochrane Central, and clinicaltrials.gov (to confirm no study has started with clinical trial). Boolean searches were performed using the defined key words “bone” and “graphene”, and manuscript abstracts were uploaded to Rayyan, a web-tool for systematic and scoping reviews. This scoping review was conducted based on Joanna Briggs Institute Manual for Scoping Reviews and the report follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Extension for Scoping Reviews (PRISMA-ScR) statement. After the search protocol and application of the inclusion criteria, 77 studies were selected and evaluated by five blinded researchers. Most of the selected studies used composite materials associated with graphene and its derivatives to natural and synthetic polymers, bioglass, and others. Although a variety of graphene materials were analyzed in these studies, they all concluded that graphene, its derivatives, and its composites improve bone repair processes by increasing osteoconductivity, osteoinductivity, new bone formation, and angiogenesis. Thus, this systematic review opens up new opportunities for the development of novel strategies for bone tissue engineering with graphene.

<b>本文件包含可上传至Rayyan系统的无重复手稿与摘要，以及EndNote文献库文件。</b><br><b>【摘要】</b>医疗领域对高性能医用材料的日益增长的需求，推动了原本相互独立的医学与工程学两大领域的交叉融合。再生医学借助工程学的技术手段不断优化医用材料与器械，实现了长足发展。就此而言，石墨烯（graphene）是骨组织工程领域最具应用前景的材料之一，其骨修复潜力已被多个研究团队深入探索。本研究旨在开展一项范围综述（scoping review），纳入2010至2022年近12年间发表的、将石墨烯及其衍生物（氧化石墨烯与还原石墨烯）应用于骨组织再生临床前研究的相关文献；检索数据库涵盖PubMed/MEDLINE、Embase、Web of Science、Cochrane中央对照试验注册库（Cochrane Central）以及clinicaltrials.gov，以确认尚无研究启动临床试验。本研究采用预设关键词"骨"与"石墨烯"开展布尔检索，并将手稿摘要上传至用于系统综述与范围综述的在线工具Rayyan。本次范围综述严格遵循《Joanna Briggs Institute范围综述手册》（Joanna Briggs Institute Manual for Scoping Reviews）开展，报告内容则符合《系统综述与Meta分析首选报告条目——范围综述扩展版》（PRISMA-ScR）的规范要求。完成检索方案制定与纳入标准筛选后，共遴选得到77项研究，并由5名盲法研究人员开展评估。入选研究中，多数将石墨烯及其衍生物与天然/合成聚合物、生物玻璃等材料复合制备复合材料。尽管上述研究分析了多种石墨烯基材料，但所有研究均得出一致结论：石墨烯及其衍生物与复合支架可通过提升骨传导性、骨诱导性、新骨形成能力与血管生成能力，优化骨修复进程。综上，本系统综述为基于石墨烯的骨组织工程创新策略开发提供了全新思路。