Predictive and diagnostic performance of Tuberculosis transcriptomic biomarker in BCG associated IRIS

RISK6 and DIAG3 signatures scores for a subset of ART-naïve HIV+ infants and young children who were enrolled into the observational multi-centered prospective clinical study in the International Maternal, Pediatric, Adolescent AIDS Clinical Trial (IMPAACT) network. Signature scores were computed from gene expression measurements performed by microfluidic RT-qPCR on mRNA derived from whole blood collected in PAXgene tubes. Also include are signature scores computed from publish microarray datasets: GSE83892 and GSE58411

本数据集涵盖纳入国际母婴、青少年艾滋病临床试验（International Maternal, Pediatric, Adolescent AIDS Clinical Trial, IMPAACT）网络多中心前瞻性观察临床研究的未接受过抗逆转录病毒治疗（Antiretroviral Therapy, ART）的HIV阳性婴幼儿及低龄儿童亚群的RISK6与DIAG3基因特征评分。上述特征评分基于采用微流控实时定量逆转录聚合酶链反应（microfluidic RT-qPCR）对PAXgene采血管采集的全血中提取的mRNA进行的基因表达检测结果计算得到。本数据集同时包含来自已发表微阵列数据集GSE83892与GSE58411的特征评分。