Burden of tuberculosis trends in a Brazilian southern state

ABSTRACT: Introduction: The burden of tuberculosis has been scarcely explored in developing countries. Objective: To estimate the trend of the burden of tuberculosis in the state of Santa Catarina, southern Brazil, from 2007 to 2011. Methods: Epidemiological time-series study on tuberculosis notifications and deaths reported in the Disease Notification System and the Mortality Information System between 2007 and 2011. Crude rates of Disability-Adjusted Life Years (DALY) and subcomponents were calculated and standardized by gender and age groups. Segmented linear regression was used to estimate the trends for burden of tuberculosis during the study period. Results: There were 696 deaths and 8,598 notifications during the study period. The highest rate was found in 2009, with 91.8 DALY/100,000 inhabitants, and the lowest in 2007, with 67.2 DALY/100,000 inhabitants. The highest burden was among men in economically active age groups. The study showed a non-significant increase of 3.8% per year in DALY rates. Conclusion: The burden of tuberculosis remained stable in Santa Catarina, Brazil between 2007 and 2011.

摘要：
引言：结核病疾病负担在发展中国家尚未得到充分探索。
研究目的：估算巴西南部圣卡塔琳娜州2007年至2011年间的结核病疾病负担变化趋势。
研究方法：本研究为流行病学时间序列研究，分析2007年至2011年期间通过疾病报告系统与死亡信息系统上报的结核病病例及死亡数据。计算伤残调整寿命年（Disability-Adjusted Life Years, DALY）及其亚组分的粗率，并按性别和年龄组进行标化。采用分段线性回归模型估算研究期间结核病疾病负担的变化趋势。
研究结果：研究期间共报告696例死亡病例与8598例结核病病例。伤残调整寿命年率最高值出现在2009年，为91.8/10万人口，最低值出现在2007年，为67.2/10万人口。疾病负担最高的群体为经济活动年龄段的男性。本研究显示，DALY率每年以3.8%的幅度非显著性增长。
结论：2007年至2011年间，巴西圣卡塔琳娜州的结核病疾病负担维持相对稳定。