Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection

The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhematopoietic cells in this difference have been evaluated with bone marrow chimeras. The results show that non-H-2 loci with a major effect on susceptibility are expressed in hematopoietic cells. However, the study of the SJL.B10-D10Mit180-D10Mit74 congenic line suggests that other loci expressed in nonhematopoietic cells also play a role.泰勒氏小鼠脑脊髓炎病毒（Theiler's murine encephalomyelitis virus）的DA毒株可在易感小鼠的脊髓白质中持续存在。既往研究结果显示，易感品系SJL/J与抗性品系B10.S之间对病毒持续感染的易感性差异，由多个非H-2基因座（non-H-2 loci）所决定。本研究通过骨髓嵌合体（bone marrow chimeras）模型，评估了造血细胞与非造血细胞在该易感性差异中的各自作用。结果表明，对病毒易感性具有主要调控效应的非H-2基因座，是在造血细胞中表达的。然而，针对SJL.B10-D10Mit180-D10Mit74同基因系的研究提示，在非造血细胞中表达的其他基因座同样参与了该易感性差异的形成。