BindingDB Entry 50046726: Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

Small molecule binding data for protein Dual specificity mitogen-activated protein kinase kinase 4, Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7), Glycogen synthase kinase-3, Macrophage colony stimulating factor receptor, Mitogen-activated protein kinase 10, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase 11, Mitogen-activated protein kinase kinase kinase 12, Mitogen-activated protein kinase kinase kinase 9, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, and c-Jun N-terminal kinase, JNK, Uniprot O14733, P04629, P07333, P10721, P12931, P36888, P45983, P45984, P45985, P49841, P53779, P80192, Q02779, Q12852, Q16584, and Q16620

本数据集包含针对以下蛋白质的小分子结合数据：双特异性丝裂原活化蛋白激酶激酶4、双特异性丝裂原活化蛋白激酶激酶7（MAP2K7）、糖原合酶激酶3、巨噬细胞集落刺激因子受体、丝裂原活化蛋白激酶10、丝裂原活化蛋白激酶9、丝裂原活化蛋白激酶激酶激酶10、丝裂原活化蛋白激酶激酶激酶11、丝裂原活化蛋白激酶激酶激酶12、丝裂原活化蛋白激酶激酶激酶9、神经营养性酪氨酸激酶受体、神经营养性酪氨酸激酶受体2型、酪氨酸蛋白激酶Kit（Kit）、酪氨酸蛋白激酶受体FLT3、血管内皮生长因子受体2、酪氨酸蛋白激酶SRC以及c-Jun氨基末端激酶（JNK）；其对应通用蛋白质知识库（Uniprot）编号为O14733、P04629、P07333、P10721、P12931、P36888、P45983、P45984、P45985、P49841、P53779、P80192、Q02779、Q12852、Q16584以及Q16620