Intergenic DNA organization in the mammalian nervous system

Eukaryotic genomes largely consist of non-coding DNA regions. Most non-coding DNA resides in intergenic DNA regions located between a gene and its nearest gene. Here, we demonstrate the relationship between intergenic DNA and gene regulation throughout the mammalian nervous system. Examination of total RNA profiles of mouse ES cell-derived spinal motor neurons by deep sequencing.

真核生物基因组（Eukaryotic genome）绝大多数由非编码DNA（non-coding DNA）区域构成。绝大多数非编码DNA存在于某一基因与其最近邻基因之间的基因间DNA区域（intergenic DNA regions）中。本研究阐明了基因间DNA与贯穿哺乳动物神经系统的基因调控过程之间的关联。本研究通过深度测序，对小鼠胚胎干细胞（mouse ES cell）诱导分化得到的脊髓运动神经元的总RNA表达谱进行了检测分析。