Replication Data for: Biocompatible Ionic Liquids in High-Performing Organic Electrochemical Transistors for Ion Detection and Electrophysiological Monitoring

Organic electrochemical transistors (OECTs) have recently attracted attention due to their high transconductance and low operating voltage, which makes them ideal for a wide range of biosensing applications. Poly-3,4-ethylenedioxythiophene:poly-4-styrenesulfonate (PEDOT:PSS) is a typical material used as the active channel layer in OECTs. Pristine PEDOT:PSS has poor electrical conductivity and additives are typically introduced to improve its conductivity and OECT performance. However, these additives are mostly either toxic or not proved to be biocompatible. Herein, a biocompatible ionic liquid [MTEOA][MeOSO3] is demonstrated to be an effective additive to enhance the performance of PEDOT:PSS based OECTs. The influence of [MTEOA][MeOSO3] on the conductivity, morphology and the redox process of PEDOT:PSS are investigated. The PEDOT:PSS/[MTEOA][MeOSO3] based OECT exhibits high transconductance (22.3 ± 4.5 mS μm-1), high μC* (the product of mobility μ and volumetric capacitance C*) (283.80 ± 29.66 F cm-1 V-1 s-1), fast response time (~40.57 μs) and excellent switching cyclical stability. Next, the integration of sodium (Na+) and potassium (K+) ion-selective membranes with the OECTs is demonstrated, enabling selective ions detection in the physiological range. In addition, flexible OECTs are designed for electrophysiological (ECG) signals acquisition. These OECTs have shown robust performance against physical deformation and successfully recorded high quality ECG signals.

有机电化学晶体管（Organic electrochemical transistors, OECTs）近年来因其高跨导性和低工作电压受到广泛关注，使其成为各类生物传感应用的理想选择。聚3,4-乙撑二氧噻吩:聚4-苯乙烯磺酸盐（Poly-3,4-ethylenedioxythiophene:poly-4-styrenesulfonate, PEDOT:PSS）是OECT中常用的活性沟道层材料。原始PEDOT:PSS的导电性较差，通常需引入添加剂以提升其导电性及OECT性能。然而，这些添加剂大多具有毒性或未被证实具有生物相容性。在此，我们证明了一种生物相容性离子液体[MTEOA][MeOSO3]可作为有效添加剂，用于提升基于PEDOT:PSS的OECT性能。研究了[MTEOA][MeOSO3]对PEDOT:PSS导电性、形貌及氧化还原过程的影响。基于PEDOT:PSS/[MTEOA][MeOSO3]的OECT表现出高跨导性（22.3±4.5 mS μm⁻¹）、高μC*（迁移率μ与体积电容C*的乘积，283.80±29.66 F cm⁻¹ V⁻¹ s⁻¹）、快速响应时间（~40.57 μs）及优异的开关循环稳定性。此外，我们展示了将钠（Na⁺）和钾（K⁺）离子选择性膜与OECT集成的方案，实现了生理范围内的选择性离子检测。同时，设计了用于电生理（ECG）信号采集的柔性OECT，这些器件在物理形变下表现出稳健性能，并成功记录了高质量的ECG信号。