Sec15 Controls STAT3 Traffic Direction to Modulate Hematopoietic Stem Cell Fate

To advance the development of our gene expression approach in uncovering regulatory pathways, we utilized whole-genome microarray expression profiling as a discovery platform to identify genes that could illuminate the role of the Sec15 gene. Liver tissues from Sec15 knockout and control mice were collected at six weeks of age to perform comparative analyses. This approach aimed to identify key gene expression changes linked to Sec15 deficiency Sec15 knockout and control mice did not receive any treatment

为推动我们在调控通路揭示领域的基因表达研究方法发展，我们采用全基因组微阵列表达谱（whole-genome microarray expression profiling）作为发现平台，以筛选可阐明Sec15基因功能的相关基因。我们于小鼠六周龄时采集Sec15基因敲除（knockout）小鼠与对照小鼠的肝脏组织，开展对比分析。本研究旨在鉴定与Sec15基因缺失相关的关键基因表达变化。所有Sec15基因敲除小鼠与对照小鼠均未接受任何实验处理。