Transcriptome sequencing of iPSC-derived motor neurons with TPD-43 knockdown

To investigate effects of TDP-43 (RNA-binding protein) to transcriptomes in motor neurons, RNA-seq for iPSC-derived motor neurons with TPD-43 knockdown were performed. Both nanopore long and Illumina short-read sequencers were used.

为探究TDP-43（RNA结合蛋白，RNA-binding protein）对运动神经元转录组的影响，本研究针对经TDP-43敲低的诱导多能干细胞（induced pluripotent stem cell, iPSC）来源运动神经元开展了RNA测序（RNA-seq）实验，并同时使用了纳米孔长读长测序仪与Illumina短读长测序仪进行测序。