Mutations in TOX3 in primary breast tumours.

aIn-silico prediction (data shown as File S2 and S3).bPAM50 classification [15], [16].cWT, only the wild-type allele is detected in the tumour mRNA; MUT, only the mutated allele is detected in the tumour mRNA; MUT = WT and MUT>WT, both mutated and wild-type alleles are detected in the tumour mRNA in equimolar amounts or the mutated allele in higher quantity.dReported in COSMIC [20].

a. 硅基模拟预测（in silico prediction），相关数据详见文件S2与S3。b. PAM50分型（PAM50 classification），相关依据引自文献[15]、[16]。c. WT（wild-type allele）：仅在肿瘤mRNA中检测到野生型等位基因；MUT（mutated allele）：仅在肿瘤mRNA中检测到突变型等位基因；当MUT与WT摩尔量相等（MUT=WT）或突变型等位基因丰度更高（MUT>WT）时，肿瘤mRNA中可同时检测到突变型与野生型两种等位基因。d. 相关数据引自癌症体细胞突变目录（COSMIC）[20]。