Whole genome sequenceing of Kingella kingae isolates from New Zealand.. Kingella kingae

Kingella kingae is a common etiology of pediatric bacteremia and causes osteomyelitis and septic arthritis in children aged 6 to 36 months. Kingella kingae is a fastidious organism that is often difficult to isolate from clinical samples. This project will collect isolates grown from culture and compare phenotypic features such as antimicrobial resistance with molecular markers. The whole genome sequences will also be analyzed for other features such as virulence factors and strain variations.

金氏杆菌（Kingella kingae）是引发儿童菌血症的常见病原菌，同时可导致6至36月龄儿童罹患骨髓炎与化脓性关节炎。该菌为苛养微生物，往往难以从临床样本中分离得到。本项目将收集经培养获得的该菌分离株，对比其抗菌药物耐药性等表型特征与分子标记物的关联；同时还将对全基因组序列进行分析，以探究毒力因子、菌株变异等其他相关特征。