GENEVA GWA mapping: Maternal Metabolism-Birth Weight Interactions. Homo sapiens

Low and high birth weight are not only major causes of neonatal morbidity and mortality, but epidemiological data have established an association between birth weight and later life risk of adult metabolic diseases. Fetal growth is determined by complex interactions between fetal genes and the maternal uterine environment. Subtle or overt variation in maternal glucose tolerance, which is, in part, genetically determined, is related to fetal size at birth. Moreover, new emerging data suggest that genetic variation in the fetus can impact maternal metabolism (e.g., blood pressure and glucose tolerance). Given the above, we are addressing the hypothesis that, during pregnancy, gene-environment interactions in the context of the maternal-fetal unit impact fetal size at birth and maternal metabolism. Genes that control fetal growth or maternal metabolism during pregnancy are largely unknown, so the first step to address our hypothesis will be to identify genetic... (for more see dbGaP study page.)

低出生体重与高出生体重不仅是新生儿发病和死亡的主要诱因，流行病学数据亦已证实出生体重与成年后代谢疾病发病风险之间存在明确关联。胎儿生长发育由胎儿自身基因与母体子宫环境之间的复杂交互作用共同决定。母体糖耐量存在细微或显著的变异，而这种变异部分由遗传因素决定，与胎儿出生时的体格大小密切相关。此外，最新研究数据表明，胎儿的遗传变异可对母体代谢产生影响（例如血压与糖耐量）。基于上述背景，本研究旨在验证如下假说：在妊娠期间，母胎单元背景下的基因-环境交互作用会影响胎儿出生体格大小与母体代谢状态。目前学界对调控妊娠期间胎儿生长或母体代谢的基因仍知之甚少，因此验证本研究假说的首要步骤将是识别相关遗传……（更多详情请参见dbGaP研究页面）