Transcriptomes of wild African green monkeys (Chlorocebus aethiops sabaeus and Chlorocebus aethiops pygerytherus) from Africa. Chlorocebus sabaeus

This project is to characterize blood transcription of wild African green monkey (AGM) from Chlorocebus aethiops pygerythrus and Chlorocebus aethiops sabaeus subspecies from Africa. These populations are heavily infected with simian immunodeffciency virus (SIV), but despite the massive exposure to SIV a substantial fraction of exposed individuals remain uninfected representing, so called Exposed Seronegative/Uninfected (ESN/EU) cohorts. We aim to identify genomic factors underlying resistance to SIV infection in this species, and apply this knowledge to develop novel theraputical strategies against human immunodeficiency virus (HIV) and AIDS.

本项目旨在对来自非洲的两个非洲绿猴（African Green Monkey, AGM）亚种——Chlorocebus aethiops pygerythrus与Chlorocebus aethiops sabaeus的野生个体的血液转录组特征进行解析。该种群广泛感染猴免疫缺陷病毒（Simian Immunodeficiency Virus, SIV），但尽管大量个体暴露于SIV，仍有相当比例的暴露个体未被感染，即所谓的暴露血清阴性/未感染（Exposed Seronegative/Uninfected, ESN/EU）队列。本研究旨在鉴定该物种抗SIV感染的潜在基因组因子，并将相关研究成果应用于开发针对人类免疫缺陷病毒（Human Immunodeficiency Virus, HIV）与艾滋病（AIDS）的新型治疗策略。