The Human Cytomegalovirus US8 Glycoprotein Binds to Major Histocompatibility Complex Class I Products

Human cytomegalovirus US8 is a type I membrane protein that partially colocalizes with cellular endosomal and lysosomal proteins. Although US8 does not have discernible effects on the processing and cell surface distribution of major histocompatibility complex (MHC) class I products, we have demonstrated that US8 binds to MHC class I heavy chains in the endoplasmic reticulum.人类巨细胞病毒（Human cytomegalovirus）US8蛋白属于I型膜蛋白，可与细胞内体及溶酶体蛋白发生部分共定位。尽管US8对主要组织相容性复合体I类（major histocompatibility complex，MHC）产物的加工过程与细胞表面分布无显著影响，但本研究证实US8可在内质网（endoplasmic reticulum）中与MHC I类重链相结合。