Chromosomal profiles of high-grade cervical intraepithelial neoplasia relate to duration of preceding high-risk human papillomavirus infection. Homo sapiens

High-grade cervical intraepithelial neoplasia (CIN2/3) represents a heterogeneous disease both with respect to clinical behaviour and chromosomal aberrations detected. We hypothesized that the extent of chromosomal aberrations reflects the duration of their existence. Chromosomal profiles were determined of CIN3 of women with a known 5 year history of high-risk human papillomavirus virus (hrHPV) infection, in which duration of prior hrHPV infection was considered a proxy for duration of CIN3 existence. Eleven women had a 5yrPHI, 6 CIN1, 6CIN3 adjacent to SCC & 6 SCC

高级别宫颈上皮内瘤变（High-grade cervical intraepithelial neoplasia, CIN2/3）是一类在临床行为与检出的染色体畸变方面均表现出异质性的疾病。我们提出研究假设：染色体畸变的程度可反映其存在时长。本研究对存在明确5年高危型人乳头瘤病毒（high-risk human papillomavirus, hrHPV）感染史的女性的CIN3样本进行了染色体谱分析，并将既往hrHPV感染时长作为CIN3存在时长的替代指标。其中11名女性存在5年既往hrHPV感染史（5yrPHI），6例为CIN1病变，6例为伴鳞状细胞癌（squamous cell carcinoma, SCC）的CIN3，另有6例鳞状细胞癌样本。