Nasal microbiomes and RNAseq of bison infected with SARS-CoV-2

SARS-CoV-2, the causative viral agent of COVID-19, is capable of infecting a broad range of mammalian species. This has implications for animal health and conservation as well as for public health due to potential for mutation in nonhuman hosts. This study assessed the effects of SARS-CoV-2 infection in North American bison (Bison bison). In addition to assessments of disease pathology and clinical signs, longitudinal analysis of the nasal microbiome was also conducted to identify additional effects caused by infection.

严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）是新型冠状病毒肺炎（COVID-19）的致病病毒病原，可感染广泛的哺乳动物类群。由于病毒在非人类宿主中存在发生突变的潜在风险，该特性对动物健康、动物保护及公共卫生均具有重要意义。本研究评估了该病毒感染对北美野牛（Bison bison）的影响。除了对疾病病理与临床症状进行评估外，本研究还对鼻腔微生物组开展了纵向分析，以识别感染所引发的其他潜在效应。