RNA-seq data: Molluscicide impedes development of Schistosoma mansoni cercariae into adult parasites. Schistosoma mansoni strain:LE

WHO recommends use of molluscicides for control of local transmission. Among those, natural plant extracts such as Euphorbia milii latex have attracted particular attention since they are sustainable and cheap. We had anecdotic evidence that E. milii latex also impacts infection outcome if treated snails were infected with S. mansoni. We tested here that transient exposure of the human dwelling larvae (cercariae) to the latex at doses that do not affect its infectivity has effects 60 days later on the morphology, physiology and fitness of the adult parasite worms. In order to generate insights into key metabolic pathways that lead to the observed phenotypes we used comparative transcriptomics and proteomics.

世界卫生组织（World Health Organization, WHO）推荐使用杀软体动物剂以防控局部传播。其中，诸如虎刺梅（Euphorbia milii）汁液等天然植物提取物因兼具可持续性与低成本优势，受到了广泛关注。我们此前已获得传闻证据：若用该汁液处理感染曼氏血吸虫（Schistosoma mansoni，S. mansoni）的钉螺，其感染结局会受到影响。本研究中，我们验证了将曼氏血吸虫尾蚴（cercariae，即寄生于人体的血吸虫幼虫）短暂暴露于该汁液且不影响其感染性的剂量下，会在60天后对成虫寄生虫的形态、生理状态与适合度产生影响。为深入解析介导上述观测表型的关键代谢通路，我们采用了比较转录组学与蛋白质组学技术。