Data_Sheet_2_A network meta-analysis of the effect of physical exercise on core symptoms in patients with autism spectrum disorders.DOCX

ObjectiveTo compare the effects of various sports exercise programs on the core symptoms of patients with autism spectrum disorder (ASD).
MethodsWe searched the China National Knowledge Infrastructure, VIP databases, Wanfang databases, Cochrane Library, PubMed, EMBASE, and Web of Science databases from their inception to February 2023 for randomized controlled trial that investigated the effect of sports exercise on the core symptoms of ASD. The overall risk of bias in the included literature was summarized using the revised Cochrane Randomized Trial Risk of Bias Tool (ROB2), and network meta-analysis was used to compare the intervention effects.
ResultsA total of 30 studies involving 1,375 participants were included. The results showed that sports exercise programs, including 8–12 weeks of ball sports (SMD = −5.35, 95%CI: −7.57, −3.23), horse riding (SMD = −3.71, 95%CI: −6.18, −1.13), 8–12 weeks of comprehensive sports exercise (SMD = −2.17, 95%CI: −3.99, −0.44), and more than 12 weeks of comprehensive sports exercise (SMD = −3.75, 95%CI: −6.33, −1.24), significantly improved social interaction disorders. Furthermore, 8–12 weeks of ball sports (SMD = −4.36, 95%CI: 2.04, 6.73) and more than 12 weeks of comprehensive sports exercise (SMD = 3.65, 95%CI: 1.40, 6.08) significantly improved repetitive behaviors and restricted interests.
ConclusionSports exercise can improve the core symptoms of ASD patients, and different symptoms show a selective response to different exercise elements.
Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023455806.

【目的】比较各类体育运动干预方案对孤独症谱系障碍（Autism Spectrum Disorder, ASD）患者核心症状的改善效果。
【方法】检索建库至2023年2月的中国知网（China National Knowledge Infrastructure）、维普数据库（VIP）、万方数据库、Cochrane图书馆、PubMed、EMBASE及Web of Science数据库，纳入探讨体育运动对ASD核心症状影响的随机对照试验（randomized controlled trial, RCT）。采用修订版Cochrane随机试验偏倚风险工具（ROB2）评价纳入文献的整体偏倚风险，并通过网状meta分析（network meta-analysis）比较各类干预措施的效应差异。
【结果】共纳入30项研究，涉及1375名受试者。结果显示，包含8~12周球类运动（标准化均数差SMD=-5.35，95%置信区间95%CI：-7.57、-3.23）、马术运动（SMD=-3.71，95%CI：-6.18、-1.13）、8~12周综合体育运动（SMD=-2.17，95%CI：-3.99、-0.44）以及12周以上综合体育运动（SMD=-3.75，95%CI：-6.33、-1.24）在内的各类体育运动方案，可显著改善患者的社交交往障碍。此外，8~12周球类运动（SMD=-4.36，95%CI：2.04、6.73）与12周以上综合体育运动（SMD=3.65，95%CI：1.40、6.08）可显著改善重复刻板行为与局限兴趣症状。
【结论】体育运动可改善孤独症谱系障碍患者的核心症状，且不同症状对不同运动干预要素存在选择性应答。
【系统评价注册】https://www.crd.york.ac.uk/prospero/，标识符：CRD42023455806。