PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).<br><br>The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004), MTMR2 (Cao et al. 2008), MTMR4 (Lorenzo et al. 2006), and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

在晚期内质网膜上，肌管蛋白（MTM1）、肌管蛋白相关蛋白2（MTMR2）、肌管蛋白相关蛋白4（MTMR4）以及肌管蛋白相关蛋白7（MTMR7）通过去磷酸化磷脂酰肌醇3,5-二磷酸（PI(3,5)P2）转化为磷脂酰肌醇5磷酸（PI5P）。以下列出了上述蛋白质及其相应的文献引用：MTM1（Cao等，2007，Cao等，2008，Tsujita等，2004，Tronchere等，2004）、MTMR2（Cao等，2008）、MTMR4（Lorenzo等，2006）和MTMR7（Mochizuki & Majerus，2003，Lorenzo等，2006）。