Dataset ON1 genotype of HRSV-A [71]

This dataset presents the molecular characterization of Human Respiratory Syncytial Virus group A (HRSV-A) genotypes circulating along the coast of Peru between 2009 and 2020. Using a retrospective analysis of 1,694 nasopharyngeal swab samples from pediatric patients hospitalized with acute respiratory infections, 53 sequences of the G glycoprotein gene were analyzed. Phylogenetic reconstructions using Bayesian inference and Maximum Likelihood methods identified the co-circulation of the NA1 and ON1 genotypes, with a newly proposed Peruvian lineage ON1[1-6] exhibiting three exclusive point mutations (S250F, S267L, and T293I). These mutations reduced O-glycosylation potential and may alter antigenic properties of the virus. Findings suggest that the ON1 genotype may have originated in South America, possibly Peru, earlier than previously reported, and emphasize the need for continuous genomic surveillance.

本数据集呈现了2009年至2020年间沿秘鲁沿海地区流行的人类呼吸道合胞病毒A组（Human Respiratory Syncytial Virus group A, HRSV-A）基因型的分子特征。研究团队针对1694份因急性呼吸道感染住院的儿科患者鼻咽拭子样本开展回顾性分析，共获取并分析了53条G糖蛋白基因（G glycoprotein gene）序列。采用贝叶斯推断（Bayesian inference）与最大似然（Maximum Likelihood）方法进行系统发育重建，结果显示NA1与ON1基因型共同流行；本次研究新提出的秘鲁源性ON1谱系ON1[1-6]携带3处独有单点突变（S250F、S267L及T293I）。上述突变可降低O-糖基化（O-glycosylation）潜能，并可能改变病毒的抗原特性。本研究结果提示，ON1基因型的起源时间或早于此前报道，其起源地可能为南美洲（或秘鲁本土），同时强调了持续开展基因组监测的必要性。