Variance explained by large region joint associations in HRS.

1 28 SNPs from [18] were tested for BMI, 16 SNPs from [20] were tested for CRP, 67 SNPs from [19] were tested for HDLc, and 180 SNPs from [17] were tested for height.
2 In the unadjusted analysis, traits were not adjusted for candidate SNPs.
3 In the adjusted analysis, traits were first adjusted for candidate SNPs associations.
4P-values were obtained from 1,000 permutations.
Variance explained by large region joint associations in HRS.

1. 针对身体质量指数（Body Mass Index, BMI），我们检验了来自文献[18]的28个单核苷酸多态性（Single Nucleotide Polymorphism, SNP）；针对C反应蛋白（C-reactive Protein, CRP），检验了来自文献[20]的16个SNP；针对高密度脂蛋白胆固醇（High-density lipoprotein cholesterol, HDLc），检验了来自文献[19]的67个SNP；针对身高，检验了来自文献[17]的180个SNP。
2. 在未校正分析中，未针对候选单核苷酸多态性对表型进行校正。
3. 在校正分析中，首先针对候选单核苷酸多态性的关联效应对表型进行校正。
4. P值通过1000次置换检验获得。
健康与退休研究（Health and Retirement Study, HRS）中大型区域联合关联所解释的方差。