Phage bacteria interaction networks differentiate ulcerative colitis and colorectal cancer from the healthy gut

Phage bacteria interactions are increasingly recognized as key drivers of gut microbiome changes in IBD and CRC. Using viral tagging, we found expanded and more complex phage host networks in UC and CRC compared to healthy controls. These results suggest condition-specific interactions that may shape gut dysbiosis in inflammatory and neoplastic diseases.

噬菌体与细菌的相互作用（Phage-bacteria interactions）日益被认为是驱动炎症性肠病（Inflammatory Bowel Disease, IBD）与结直肠癌（Colorectal Cancer, CRC）患者肠道微生物组变化的关键因素。本研究通过病毒标记法（viral tagging）发现，与健康对照相比，溃疡性结肠炎（Ulcerative Colitis, UC）和结直肠癌（CRC）患者体内的噬菌体宿主网络更为扩增且结构更趋复杂。上述结果提示存在疾病特异性的互作模式，此类互作可能参与塑造炎症性与肿瘤性疾病中的肠道菌群失调状态。