Evaluation of Galectin-3 and Myocardial Fibrosis in Patients with Hypertrophic Cardiomyopathy

Abstract Background: Galectin-3 is the designation given to the protein that binds to ß-galactosides, expressed by activated macrophages and described as a cardiac fibrosis mediator. In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is an independent predictor of adverse outcome; however, the association between Galectin-3 and myocardial fibrosis has not been studied in this cardiopathy. Objective: To evaluate the association of Galectin-3 and the presence of myocardial fibrosis in a patient with hypertrophic cardiomyopathy. Methods: Galectin-3 was measured in automated equipment using the Elisa technique in 100 participants divided into two groups: 50 patients with hypertrophic cardiomyopathy and 50 healthy control subjects. All patients with hypertrophic cardiomyopathy underwent magnetic nuclear resonance with the late enhancement technique to investigate myocardial fibrosis. For the statistical analysis, p values

摘要 背景：半乳糖凝集素3（Galectin-3）是一类可结合β-半乳糖苷的蛋白质，由活化巨噬细胞表达，被定义为心脏纤维化介质。在肥厚型心肌病（HCM）中，心肌纤维化是不良预后的独立预测因子，但目前尚未在该类心肌病中开展半乳糖凝集素3与心肌纤维化关联的相关研究。目的：评估肥厚型心肌病患者中半乳糖凝集素3水平与心肌纤维化存在情况的关联。方法：本研究纳入100名受试者，分为两组各50例：50例肥厚型心肌病患者与50名健康对照者，采用Elisa技术在自动化设备中检测受试者的半乳糖凝集素3水平。所有肥厚型心肌病患者均接受晚期强化磁共振成像技术检查以评估心肌纤维化情况。统计学分析采用p值