Inflammatory response in HSPC of PTPN11-mutated JMML

Activating mutations in PTPN11 gene are the most frequent in JMML patients. Here we explore the transcriptome of HSPC (hematopoietic stem and progenitor cells) sorted from sporadic JMML patients with PTPN11 mutation and from healthy age matched donnors. Bulk transcriptome of sorted HSPC reveals an inflammatory gene expression signature which may represent a future target for JMML therapy. Overall design: RNAseq data

PTPN11基因的激活突变是幼年型粒-单核细胞白血病（JMML）患者中最为常见的突变类型。本研究对携带PTPN11突变的散发性JMML患者，以及年龄匹配的健康供者分选得到的造血干细胞与祖细胞（hematopoietic stem and progenitor cells，HSPC）的转录组进行了分析。对上述分选后HSPC的批量转录组测序结果显示，其存在特征性炎症基因表达谱，该谱式或可作为JMML未来治疗的潜在靶点。整体实验设计：RNA测序（RNA-seq）数据集。