Pharmacokinetic data for Doxil and doxorubicin obtained from a human clinical trial [12].

The parameters A, B, α, and β were reported by Gabizon et al. from a clinical trial from a fit to the amount of drug in circulation at time t after administration using a dual exponential decay model: Nbl(t) = Ae-αt + Be-βt, where t is the time and α and β are decay constants. A and B are reported in units of mg, using a blood volume of 5 L. The rate constants k12 (= kp), k21 (= kd), and k10 are obtained from the parameters A, B, α, and β by assuming a two-compartment model (see Text B in S1 File for details).
Pharmacokinetic data for Doxil and doxorubicin obtained from a human clinical trial [12].

Gabizon等人于一项临床试验中报道了参数A、B、α及β，该组参数通过双指数衰减模型（dual exponential decay model）拟合给药后时刻t的循环药物药量得到，模型表达式为：$N_{bl}(t) = A e^{-alpha t} + B e^{-eta t}$，其中t为时间，α与β为衰减常数。参数A与B的单位为毫克（mg），计算时采用的血容量为5升（L）。速率常数$k_{12}$（= $k_p$）、$k_{21}$（= $k_d$）及$k_{10}$可基于二室模型（two-compartment model）由参数A、B、α及β推导得到，详细推导过程见附件S1文件中的文本B。
本数据集包含从一项人体临床试验[12]中获取的Doxil与多柔比星（doxorubicin）的药代动力学数据。