X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2 Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Vecchio, A.J, Malkowski, M.G. Deposit date: 2011-09-27 Release date: 2012-04-25 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE. J.Biol.Chem., 287, 2012

本数据集为结合于G533V突变型小鼠环氧化酶-2（cyclooxygenase-2, COX-2）环氧合酶通道内的花生四烯酸（arachidonic acid）的X射线晶体结构。相关配体描述如下：1,2-乙二醇、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等。作者：Vecchio, A.J.、Malkowski, M.G.。提交日期：2011-09-27；发布日期：2012-04-25；最后更新日期：2024-11-27。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15 Å。引用文献："Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE"（探究环氧化酶-2的底物混杂性：精氨酸120与疏水沟槽周边残基的作用），刊载于J.Biol.Chem. 2012年第287卷。