Responses to Immunization with Keyhole Limpet Hemocyanin (KLH) Administered by Scarification and the Intradermal (ID) Route (KLH 07)

Atopic dermatitis (AD) is a skin disorder in which people often have swelling and skin infections. People with this disease cannot receive the smallpox vaccine because it could cause them to have a fatal reaction known as eczema vaccinatum (EV). Keyhole limpet hemocyanin (KLH) is a protein that can be used to deliver vaccines to the body. The purpose of this study is to determine a baseline immune reaction to KLH in people without AD. Once this has been established, other studies can be designed to determine whether KLH can be used to give vaccines to people with AD.

特应性皮炎（Atopic dermatitis, AD）是一种皮肤疾病，患者常伴有皮肤肿胀与感染症状。此类患者无法接种天花疫苗，因其可能引发一种名为湿疹痘（eczema vaccinatum, EV）的致命反应。钥孔戚血蓝蛋白（Keyhole limpet hemocyanin, KLH）是一种可用于向体内递送疫苗的蛋白质。本研究旨在确定无AD人群对KLH的基线免疫反应；一旦该基线确立，即可设计后续研究以探究KLH是否可用于为AD患者接种疫苗。