Bone Marrow Transplant Procedures

Procedure concept set that includes transplant of both autogenic and allogenic bone marrow, stem cells. It was developed by searching for terms such as "bone marrow", "hematopoietic stem cell", and "Blood Stem Cells & Transfusion", followed by selective removal of the false positive. It was developed by the collaborating PI Sarah Dain, MD who used Atlas to build the codeset. Chart review were not performed formally, however this study involves tying back to the EHR data at CHOP. Hence a dual approach was used where patients identified using this codeset and the bone marrow registry/dataset that PI had were used together to create the study variable. The intention of this concept set was to identify a list of patients receiving bone marrow transplant. For our study use case, bone marrow transplant was a variable (covariate). The codeset was developed to be as broad as possible. Elimination of vocabularies such as Nebraska Lexicon, MedDRA, and NAACCR was performed. The concept set includes some vocabularies not typically found in procedures; these were not used in variable construction.

本程序概念集涵盖自体与异体骨髓、干细胞移植操作。该概念集通过检索「骨髓」「造血干细胞」「血液干细胞与输血」等术语，并经选择性剔除假阳性条目后构建而成。本代码集由合作首席研究员（Principal Investigator，PI）莎拉·戴恩（Sarah Dain）医学博士开发，其借助Atlas工具完成代码集的搭建。研究未开展正式的病历审查，但需回溯CHOP院内的电子健康记录（Electronic Health Record，EHR）数据。因此采用双轨验证方案：将通过本代码集识别出的患者，与该PI所持有的骨髓登记数据集进行关联，共同构建研究变量。本概念集的设计初衷为筛选接受骨髓移植的患者队列。在本研究的应用场景中，骨髓移植被设为协变量（covariate）。本代码集的构建力求覆盖范围最大化。已剔除内布拉斯加词表（Nebraska Lexicon）、医药监管活动医学词典（Medical Dictionary for Regulatory Activities，MedDRA）以及北美中央癌症登记协会（North American Association of Central Cancer Registries，NAACCR）等词汇集。本概念集包含部分非典型手术操作类词汇，但此类词汇未被用于研究变量的构建流程。