ROSMAP meQTL Results for Bulk cells with regionalpcs and averages

This dataset contains methylation quantitative trait loci (meQTL) results for the following study: "regionalpcs improve discovery of DNA methylation associations with complex traits" Tiffany Eulalio*1, Min Woo Sun1, Olivier Gevaert1, Michael D. Greicius2, Thomas J. Montine3, Daniel Nachun*‡3, Stephen B. Montgomery*‡1,3 ‡ These authors contributed equally as senior authors * Corresponding authors: Tiffany Eulalio ([e-mail]), Daniel Nachun ([e-mail]), Stephen B. Montgomery ([e-mail]) Author affiliations: 1. Department of Biomedical Data Science, Stanford University, Stanford, CA 2. Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA 3. Department of Pathology, Stanford University, Stanford, CA Dataset description: This dataset contains QTL results generated from FastQTL, organized by region type (full gene, gene body, preTSS, and promoters) and summary types (averages and regional principal components). Contents: Parquet tar files: These compressed archives contain output files in Parquet format from FastQTL, split by chromosome. parquet1 includes chromosomes 1-10, and parquet2 includes chromosomes 11-22. cis_qtl_summary_stats.csv: Provides summary statistics for each phenotype-variant pair, including effect sizes, p-values, TSS distances, and additional details. cis_qtl.signif_pairs.csv: Contains the significant QTL results identified by FastQTL. cis_qtls.time_to_run.txt: Reports the running time for FastQTL analysis. cis_qtls.cis_qtl.txt.gz: Contains comprehensive results for all cis QTLs. This dataset is intended to support replication and further exploration of QTL associations across different genomic regions and summary methods.本数据集包含下述研究的甲基化数量性状位点（methylation quantitative trait loci, meQTL）分析结果： "区域主成分优化复杂性状DNA甲基化关联的发掘" 作者：Tiffany Eulalio*1, Min Woo Sun1, Olivier Gevaert1, Michael D. Greicius2, Thomas J. Montine3, Daniel Nachun*‡3, Stephen B. Montgomery*‡1,3 ‡ 上述作者为同等贡献的共同通讯作者 * 通讯作者：Tiffany Eulalio（邮箱：[e-mail]）、Daniel Nachun（邮箱：[e-mail]）、Stephen B. Montgomery（邮箱：[e-mail]） 作者单位： 1. 斯坦福大学生物医学数据科学系，美国加利福尼亚州斯坦福市 2. 斯坦福大学神经病学与神经科学系，美国加利福尼亚州斯坦福市 3. 斯坦福大学病理学系，美国加利福尼亚州斯坦福市 数据集说明： 本数据集包含由FastQTL生成的QTL分析结果，按区域类型（全基因区、基因本体区、转录起始位点上游区（preTSS）及启动子区）与汇总类型（均值与区域主成分）进行组织。 数据集内容： Parquet压缩归档文件：此类压缩存档包含FastQTL输出的Parquet格式文件，按染色体拆分。parquet1包含1至10号染色体，parquet2包含11至22号染色体。 cis_qtl_summary_stats.csv：提供每个表型-变异对的汇总统计信息，包括效应量、p值、转录起始位点距离及其他详细信息。 cis_qtl.signif_pairs.csv：包含FastQTL鉴定得到的显著QTL分析结果。 cis_qtls.time_to_run.txt：记录FastQTL分析的运行时长。 cis_qtls.cis_qtl.txt.gz：包含所有顺式QTL的完整分析结果。 本数据集旨在支持不同基因组区域与汇总方法下的QTL关联的重复验证与进一步探索研究。