Global gene expression analysis of human monocyte-derived dendritic cells (DCs) treated with HMGN1 (N1) and R848 alone or in combination.. Global gene expression analysis of human monocyte-derived dendritic cells (DCs) treated with HMGN1 (N1) and R848 alone or in combination.

RNA-seq data demonstrate that N1 plus R848 at the global gene expression level synergistically promotes DC maturation and subsequent upregulation of many genes in DCs that are involved in the polarization of CD4+ T cells into Th1-type effectors. Overall design: DCs sham-treated or treated with N1, R848, or N1 plus R848 for 4 hours.

转录组测序（RNA-seq）数据显示，从全基因表达水平来看，N1联合R848可协同促进树突状细胞（Dendritic Cell, DC）成熟，并随后上调树突状细胞中诸多参与CD4阳性T细胞（CD4+ T cells）极化为Th1型效应细胞（Th1-type effectors）的基因。实验设计概述：将树突状细胞进行假处理，或分别用N1、R848、N1联合R848处理4小时。