Genomic and functional diversity of the human-derived isolates of Faecalibacterium

Faecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of Faecalibacterium genomes from cultured strains and the distribution of different species in populations may differ among different sources. We here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 Faecalibacterium genomes collected from 10 countries. The genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated.

粪杆菌属（Faecalibacterium）是健康成年人肠道微生物群中丰度最高的细菌类群之一，被广泛视为下一代益生菌。然而，不同来源的可培养菌株的粪杆菌属基因组功能，以及不同菌种在人群中的分布特征可能存在差异。本研究对来自10个国家的136个粪杆菌属基因组开展了全面的泛基因组、功能及安全性评价分析。这些基因组被划分为11个簇，其中仅5个簇已得到表征并完成有效命名。