One-Pot Synthesis of 7,9-Dialkylpurin-8-one Analogues: Broad Substrate Scope

The
one-pot and direct synthesis of 7,9-dialkyl­purin-8-one analogues
with broad substrate scope has been developed. This copper-catalyzed
C–H oxidation reaction could avoid multistep synthesis of quaternary
ammonium salts and expand the scope of halogenated alkanes. Moreover,
benzimida­zole derivatives are also applicable in the catalytic
system.

本研究开发了一种底物适用范围宽泛的7,9-二烷基-8-嘌呤酮类似物一锅法直接合成方法。该铜催化C-H氧化反应可规避季铵盐的多步合成，同时拓宽了卤代烷烃的底物适用范围。此外，苯并咪唑衍生物同样适用于该催化体系。