The Human Virome in Children and its Relationship to Febrile Illness. The Human Virome in Children and its Relationship to Febrile Illness

Definition of the human microbiome is an important scientific priority. This study will expand the scope of the investigation to include viruses, which account for a substantial proportion of infectious disease morbidity and mortality, especially in children. The long-term goal of this project is to describe the human virome in children and to investigate its relevance to febrile illnesses in children. The project will also seek to understand the relationship of the immune system to the composition of the virome. Thus, the project's specific aims are 1) To elucidate the spectrum of viruses that can be detected using non-biased, high throughput sequencing on samples of blood, respiratory, and gastrointestinal secretions from healthy children and to use this information as a basis for... (for more see dbGaP study page.)

阐明人类微生物组（human microbiome）的内涵是一项重要的科学优先研究方向。本研究将拓展调查范畴，纳入病毒相关内容——病毒在感染性疾病的发病率与死亡率中占据显著比例，尤其对儿童群体影响突出。本项目的长期目标为刻画儿童人类病毒组（human virome）的特征，并探究其与儿童发热性疾病的关联。此外，本项目还将致力于解析免疫系统与病毒组构成之间的相互关系。据此，本项目的具体研究目标如下：1）采用无偏倚高通量测序技术，对健康儿童的血液、呼吸道及胃肠道分泌物样本进行检测，明确可被检出的病毒谱系，并以此为基础开展后续研究……（更多详情请参见dbGaP研究页面）