Data_Sheet_1_Physical exercise frequency and cognition: a multicenter cross-sectional cohort study.docx

Background and aimsDementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults.Methods16,181 Chinese participants aged 65 years or older were included in this study. Associations between PE and cognition were estimated multivariate logistic and linear regression analyses. Associations were further investigated across dementia subtypes (Alzheimer dementia, vascular dementia, and other types of dementia). Subgroup analyses were performed in different age groups, in populations with and without stroke, and those with and without hypertension.ResultsPE associated with dementia after adjusting for full covariates (OR: 0.5414, 95% CI: 0.4536–0.6491, p

背景与目标：痴呆症对社会的家庭造成了沉重的负担，因此，有效的药物治疗、探索和预防与痴呆症相关联的因素至关重要。为提供最佳运动频率（身体锻炼）的参考点，本研究调查了身体锻炼频率与我国老年成年人认知能力之间的关联。方法：本研究纳入了16,181名年龄在65岁或以上的中国参与者。通过多元逻辑回归和线性回归分析估计了身体锻炼与认知能力之间的关联。进一步对痴呆症亚型（阿尔茨海默病痴呆、血管性痴呆和其他类型的痴呆）进行了关联研究。在不同年龄段、有和无中风的人群以及有和无高血压的人群中进行了亚组分析。结果：在调整了全部协变量后，与痴呆症相关的身体锻炼（OR：0.5414，95% CI：0.4536–0.6491，p<0.001）与认知能力之间存在显著关联。