Additional file 1 of Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits

Additional file 1: Table S1: Number of samples per cohort and per obesity-related cytokine and hormone. Table S2: Total number of genome-wide significant (P-value < 5×10-8) loci detected in the discovery cohort, number of novel loci, and number of loci replicated in African Americans per trait and per model. Table S3: Variants at genome-wide significance of P-value < 5×10-8 with low MAF (<5%) before and after removal of high leverage points based on Cook's distance. Table S4: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for the meta-analysis of discovery and replication cohorts combined. Table S5: Genome-wide significant loci from base model analyses with moderate or strong evidence for colocalization with eQTL data from GTEx. Table S6: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for men only. Table S7: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for women only. Table S8: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for lean (BMI < 25.0 kg/m2) individuals only. Table S9: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for overweight (BMI ≥ 25.0 kg/m2) individuals only. Table S10: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for T2D controls only. Table S11: Variants at genome-wide significance of P-value < 5×10-8 per adipocytokine/hormone for T2D cases only. Table S12: Canonical pathways for genes annotated to genome-wide significant and suggestive loci in the base model

附加文件1：表S1：各队列以及每一项肥胖相关细胞因子和激素的样本量。表S2：发现队列中检测到的全基因组显著（P值<5×10⁻⁸）位点总数、新位点数量，以及按性状与模型分类的非裔美国人群体中复制的位点数量。表S3：基于库克距离（Cook's distance）剔除高杠杆点前后，次要等位基因频率（MAF, minor allele frequency）<5%的全基因组显著（P值<5×10⁻⁸）变异位点情况。表S4：合并发现队列与复制队列开展荟萃分析时，每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S5：基础模型分析得到的全基因组显著位点，这些位点与GTEx数据库的表达数量性状位点（eQTL, expression Quantitative Trait Locus）数据存在中等至强共定位证据。表S6：仅针对男性群体，每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S7：仅针对女性群体，每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S8：仅针对消瘦个体（体质量指数BMI, Body Mass Index<25.0 kg/m²），每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S9：仅针对超重个体（BMI≥25.0 kg/m²），每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S10：仅针对2型糖尿病（T2D, Type 2 Diabetes）对照人群，每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S11：仅针对2型糖尿病（T2D, Type 2 Diabetes）病例人群，每一项脂肪细胞因子/激素对应的全基因组显著（P值<5×10⁻⁸）变异位点。表S12：基础模型中注释到全基因组显著与提示性位点的基因所对应的经典通路。